反应 #1303

反应方程式

4-bromophenylacetic acid

H2SO4

ethanol

K2CO3

→

title compound

Ethyl (4-bromophenyl)acetate

反应条件

后处理

1. 1
   过滤filtered
2. 2
   浓缩The filtrate was concentrated in vacuo
3. 3
   workup.ADDITIONdiluted with Et2O (200 ml)
4. 4
   洗涤washed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml)
5. 5
   干燥dried over MgSO4
6. 6
   浓缩concentrated in vacuo

实验过程

A solution of 43 g (200 mmol) of 4-bromophenylacetic acid and 0.2 g of conc. H2SO4 in 470 ml of ethanol was refluxed for 16 hours. The reaction mixture was cooled to ambient temperature, stirred with 6 g of solid K2CO3 for 30 minutes and then filtered. The filtrate was concentrated in vacuo, diluted with Et2O (200 ml), washed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml), dried over MgSO4 and concentrated in vacuo to give the title compound as a colorless oil.

来源