反应 #1269905

反应方程式

1′-benzyl-6-fluoro-3H-spiro[2-benzofuran-1,4′-piperidine]

→

6-fluoro-3H-spiro[2-benzofuran-1,4′-piperidine]

收率 96.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度The mixture was refluxed under an hydrogen atmosphere for 8 hours
2. 2
   其他purged with argon
3. 3
   过滤The catalyst was filtered
4. 4
   浓缩the filtrate was concentrated in vacuo

实验过程

To a solution of 1′-benzyl-6-fluoro-3H-spiro[2-benzofuran-1,4′-piperidine] (1 g, 3.4 mmol) in ethanol (10 ml) was added Pd/C 10% (100 mg, 0.09 mmol). The mixture was refluxed under an hydrogen atmosphere for 8 hours then cooled to room temperature and purged with argon. The catalyst was filtered and the filtrate was concentrated in vacuo to yield 0.67 g (96%) 6-fluoro-3H-spiro[2-benzofuran-1,4′-piperidine] as a white solid. MS m/e: 208 (M+H+).

来源