反应 #1269888

反应方程式

water

5-Amino-2-butylisoindolin-1-one

K2CO3

(2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate

→

2-butyl-5-((2,6-dimethyl-4-phenylpyridin-3-yl)methylamino)isoindolin-1-one

收率 41.3%

溶剂

DMF

反应条件

后处理

1. 1
   萃取the mixture was extracted with EtOAc
2. 2
   洗涤the combined organic layers were washed with water
3. 3
   干燥dried (MgSO4)
4. 4
   其他Purification by flash chromatography (DCM/MeOH, gradient 2-8% MeOH)

实验过程

5-Amino-2-butylisoindolin-1-one (63.1 mg, 0.309 mmol), K2CO3 (85 mg, 0.618 mmol) and KI (51.3 mg, 0.309 mmol) were added to a solution of (2,6-dimethyl-4-phenylpyridin-3-yl)methyl methanesulfonate (90 mg, 0.309 mmol) in DMF (6 mL). After stirring overnight, water was added, the mixture was extracted with EtOAc, the combined organic layers were washed with water and dried (MgSO4). Purification by flash chromatography (DCM/MeOH, gradient 2-8% MeOH) provided 2-butyl-5-((2,6-dimethyl-4-phenylpyridin-3-yl)methylamino)isoindolin-1-one (51 mg, 40%).

来源