反应 #1269864

ord-0e0040061bf441e9a8a07973c85a197f

反应方程式

O=C(O)c1nc(-c2ccccc2)c(Br)s1
5-bromo-4-phenyl-thiazole-2-carboxylic acid
CCCCOC(=O)N1CCN(C(=O)[C@@H](N)CCC(=O)OC(C)(C)C)CC1
(S)-4-(2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester
CCCCOC(=O)N1CCN(C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c2nc(-c3ccccc3)c(Br)s2)CC1
4-{(S)-2-[(5-Bromo-4-phenyl-thiazole-2-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid butyl ester

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他This compound was prepared

实验过程

This compound was prepared using a method analogous to that of Example 8, step 8.5, intermediate 48.3 replacing 5-bromo-4-phenyl-thiazole-2-carboxylic acid and (S)-4-(2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester replacing intermediate 8.4.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08664203B2uspto-grants-2014_03