反应 #1269863

反应方程式

4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester

HCl

→

4-(2-Amino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride

溶剂

Et2O

CH2Cl2

反应条件

后处理

1. 1
   过滤the white cake was filtered
2. 2
   洗涤washed with Et2O
3. 3
   其他dried at HV overnight
4. 4
   其他The crude (1.19 g) was used without purification

实验过程

To a solution of 4-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propionyl)-piperazine-1-carboxylic acid butyl ester (1.79 g, as described in WO2008044217) in CH2Cl2 (22 mL) was added HCl (4M in dioxane, 8.3 mL) and the reaction mixture was stirred for 2 h at RT. The suspension was diluted with Et2O (1000 mL) and the white cake was filtered, washed with Et2O and dried at HV overnight. The crude (1.19 g) was used without purification.

来源