反应 #1269862

反应方程式

4-((S)-2-amino-3-methyl-butyryl)-piperazine-1-carboxylic acid butyl ester

phenyl-1,3-thiazole-4-carboxylic acid

→

4-{(S)-3-Methyl-2-[(2-phenyl-thiazole-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他This compound was prepared
2. 2
   其他The compound was however purified by CC (EtOAc/Hept 0:1 to EtOAc/Hept 1:0)

实验过程

This compound was prepared using a method analogous to that of Example 8, step 8.3, 4-((S)-2-amino-3-methyl-butyryl)-piperazine-1-carboxylic acid butyl ester (prepared as described in WO2008044217) replacing piperazine-1-carboxylic acid butyl ester, phenyl-1,3-thiazole-4-carboxylic acid replacing intermediate 8.2 and using CH2Cl2 instead of CH2Cl2/THF. The compound was however purified by CC (EtOAc/Hept 0:1 to EtOAc/Hept 1:0).

来源