反应 #1269856

ord-b18ea077512946b7a1675ba41bd07ef0

反应方程式

CCOC(=O)N1CCNCC1
piperazine-1-carboxylic acid ethyl ester
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)O
Boc-Phe(4-I)-OH
→
CCOC(=O)N1CCN(C(=O)[C@H](Cc2ccc(I)cc2)NC(=O)OC(C)(C)C)CC1
4-[(S)-2-tert-Butoxycarbonylamino-3-(4-iodo-phenyl)-propionyl]-piperazine-1-carboxylic acid ethyl ester

反应物

CCOC(=O)N1CCNCC1
piperazine-1-carboxylic acid ethyl ester
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)O
Boc-Phe(4-I)-OH

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他This compound was prepared

实验过程

This compound was prepared using a method analogous to that of Example 8, step 8.3, piperazine-1-carboxylic acid ethyl ester replacing piperazine-1-carboxylic acid butyl ester and Boc-Phe(4-I)-OH replacing intermediate 8.2.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08664203B2uspto-grants-2014_03