反应 #1269854

ord-cccfcdbf19ce4846b8c0fd01c961059f

反应方程式

COC(=O)[C@H](CI)NC(=O)OC(C)(C)C
Boc-3-iodo-L-Ala-OMe
CCOP(OCC)OCC
triethyl phosphite
→
CCOP(=O)(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)OCC
oil
CCOP(=O)(C[C@H](NC(=O)OC(C)(C)C)C(=O)OC)OCC
(R)-2-tert-butoxycarbonylamino-3-(diethoxy-phosphoryl)-propionic acid methyl ester

反应物

COC(=O)[C@H](CI)NC(=O)OC(C)(C)C
Boc-3-iodo-L-Ala-OMe
CCOP(OCC)OCC
triethyl phosphite

试剂

无

反应条件

温度
130°CELSIUS
详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他evaporated to dryness

实验过程

Boc-3-iodo-L-Ala-OMe (9.4 g) was dissolved in triethyl phosphite (100 mL). The mixture was heated at 130° C. overnight and evaporated to dryness to give a yellow oil (8.37 g). The compound was used in the next step without further purification.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08664203B2uspto-grants-2014_03