反应 #1269852

反应方程式

4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester

2-phenyl-1,3-thiazole-4-carboxylic acid

DIPEA

TBTU

→

desired product

收率 49.0%

4-{2-[(2-Phenyl-thiazole-4-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid ethyl ester

收率 49.0%

溶剂

DMF

DMF

DMF

反应条件

后处理

1. 1
   其他the reaction mixture was directly purified by preparative HPLC (IV)

实验过程

To a solution of 2-phenyl-1,3-thiazole-4-carboxylic acid (5.1 mg) and DIPEA (3 eq) in DMF (0.4 mL) was added TBTU (1.2 eq) in DMF (0.2 mL). Then, a solution of 4-(2-amino-acetyl)-piperazine-1-carboxylic acid ethyl ester (5.4 mg, prepared as described in WO2006114774) in DMF (0.2 mL) was added. After stirring overnight at RT, the reaction mixture was directly purified by preparative HPLC (IV) to give 4.9 mg of the desired product.

来源