反应 #1269843

反应方程式

DBU

BOP

3-Methyluracil

(1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt

→

product

收率 76.5%

2-((1R,2R)-2-hydroxycyclopentylamino)-3-methylpyrimidin-4(3H)-one

收率 76.5%

溶剂

DMF

反应条件

后处理

1. 1
   workup.STIRRINGThe mixture was stirred at room temperature overnight
2. 2
   其他The reaction mixture was purified by a semi-preparative HPLC

实验过程

3-Methyluracil (12.6 mg, 0.1 mmol) was dissolved in 0.5 mL of DMF, and then BOP (71 mg, 0.16 mmol) was added. The mixture was stirred at room temperature for two minutes, then (1R,2R)-(−)-2-hydroxycyclopentylamine hydrochloride salt (22 mg, 0.16 mmol) was added, followed by DBU (51 uL, 3.4 mmol). The mixture was stirred at room temperature overnight. The reaction mixture was purified by a semi-preparative HPLC to give pure product (16 mg, yield 76%). MS (ESI) m/z 210.1 [M+H]+.

来源