反应 #1269839

反应方程式

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

溶剂

piperidine

dimethylformamide

反应条件

后处理

1. 1
   浓缩The reaction mixture is concentrated under vacuum, water
2. 2
   workup.ADDITIONis added to the residue
3. 3
   萃取the product is extracted with ethyl acetate
4. 4
   其他The crude product is purified by conversion into its hydrochloride salt

实验过程

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) is dissolved in 20% piperidine in dimethylformamide at 0° C. The solution is continued stifling for 1 h. The reaction mixture is concentrated under vacuum, water is added to the residue, and the product is extracted with ethyl acetate. The crude product is purified by conversion into its hydrochloride salt.

来源