反应 #1269819

反应方程式

2-bromo-2,2-difluoroethanol

pivaloyl chloride

2-bromo-2,2-difluoroethanol

1,1-difluoro-2-hydroxyethanesulfonate

ethyl bromodifluoroacetate

→

2-bromo-2,2-difluoroethyl pivalate

反应条件

实验过程

On the other hand, the 1,1-difluoro-2-hydroxyethanesulfonate of the general formula (17) can be prepared by reducing ethyl bromodifluoroacetate to 2-bromo-2,2-difluoroethanol, esterifying the 2-bromo-2,2-difluoroethanol with pivaloyl chloride to form 2-bromo-2,2-difluoroethyl pivalate, sulfinating the 2-bromo-2,2-difluoroethyl pivalate to form 1,1-difluoro-2-(pivaloyloxy)ethanesulfinate, oxidizing the 1,1-difluoro-2-(pivaloyloxy)ethanesulfinate to 1,1-difluoro-2-(pivaloyloxy)ethanesulfonate, and then, saponifying the 1,1-difluoro-2-(pivaloyloxy)ethanesulfonate. Any known esterification technique can be adopted to react the carboxylic acid derivative of the general formula (16) and the 1,1-difluoro-2-hydroxyethanesulfonate of the general formula (17) for production of the polymerizable fluorine-containing sulfonate compound of the general formula (3) as indicated in SCHEME (1).

来源