反应 #1261309

反应方程式

product

2-methoxyethanethioamide

ethyl bromopyruvate

magnesium sulfate

→

title compound

收率 57.0%

ethyl 2-(methoxymethyl)-1,3-thiazole-4-carboxylate

收率 57.0%

溶剂

acetone

反应条件

后处理

1. 1
   温度heated
2. 2
   温度at reflux for 16 hours
3. 3
   过滤filtered
4. 4
   浓缩concentrated
5. 5
   其他The residue was chromatographed on silica gel eluting with chloroform

实验过程

A solution containing the product from Example 6B (7 g, 66.6 mmol) in acetone (270 mL) was treated with ethyl bromopyruvate (8.4 mL, 66.6 mmol) and magnesium sulfate (7.9 g, 66.6 mmol), heated at reflux for 16 hours, cooled to 25° C., filtered and concentrated. The residue was chromatographed on silica gel eluting with chloroform to give the title compound (7.6 g, 57% yield).

来源