反应 #1256770

反应方程式

4-Isoxazolo[4,5-c]pyridin-3-yl-piperazine-1-carboxylic acid tert-butyl ester

HCl

dioxane

→

3-piperazin-1-yl-isoxazolo[4,5-c]pyridine dihydrochloride

溶剂

CH2Cl2

反应条件

后处理

1. 1
   过滤After dilution with iPr2O the product was collected by filtration
2. 2
   洗涤washed with one portion of iPr2O
3. 3
   其他before drying it under high vacuum at 50° C.
4. 4
   其他to obtain 850 mg (97%) as a pink solid

实验过程

4-Isoxazolo[4,5-c]pyridin-3-yl-piperazine-1-carboxylic acid tert-butyl ester (960 mg, 3.1 mmol) was dissolved in CH2Cl2 (2 ml) and 4 N HCl in dioxane (15.7 ml, 63 mmol) was added. The resulting mixture was stirred 16 h at r.t. After dilution with iPr2O the product was collected by filtration and washed with one portion of iPr2O before drying it under high vacuum at 50° C. to obtain 850 mg (97%) as a pink solid. m/z=205.2 ([M+H]+).

来源