反应 #1256766

反应方程式

5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

N-(2-bromoethyl)phthalimide

→

title compound

4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

反应条件

实验过程

The title compound was prepared from 5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester and N-(2-bromoethyl)phthalimide as described in Example 1. 1H NMR (CDCl3) δ 7.85 (m, 4H), 7.75 (m, 4H), 7.55-7.45 (m, 2H), 7.4-7.35 (m, 1H), 7.25-7.2 (m, 1H), 4.2-4.0 (m, 6H), 3.9-3.85 (m, 1H), 3.65-3.55 (m, 3H), 3.4 (br s, 1H), 2.4 (s, 3H), 2.4-2.35 (m, 1H), 1.35-1.15 (m, 3H). MS (ES) m/z 583 (MNa)+

来源