反应 #1256762

反应方程式

ammonium acetate

ethyl cyanoacetate

1-acetyl-cyclopropanecarboxylic acid ethyl ester

4-nitrobenzaldehyde

→

product

收率 43.4%

1-[5-Cyano-4-(4-nitro-phenyl)-6-oxo-1,6-dihydro-pyridin-2-yl]-cyclo-propanecarboxylic acid ethyl ester

收率 43.4%

反应条件

实验过程

In analogy to GP 1, reaction of 28.9 g ammonium acetate (375 mmol, 8 eq.), 5 ml ethyl cyanoacetate (47.3 mmol, 1 eq.), 7.32 g 1-acetyl-cyclopropanecarboxylic acid ethyl ester (47 mmol, 1 eq.), and 7.08 g 4-nitrobenzaldehyde (47 mmol, 1 eq.) yielded 7.2 g product (43% yield).

来源