反应 #1256761
ord-c78e5b8102d14f3191e48e7d7edd776b
反应方程式
trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester
hydrazine hydrate
→
product
收率 26.0%
1-[4-(3-amino-6-cyclopropyl-1H-pyrazolo[3,4-b]pyridin-4-yl)-phenyl]-3-(2-fluoro-phenyl)-urea
收率 26.0%
反应物
试剂
无
反应条件
详细条件
See reaction.notes.procedure_details.
实验过程
In analogy to the GP 5, reaction of 175 mg trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester (0.336 mmol) with 62 μl 80% hydrazine hydrate in 1-propanol yielded 35 mg product (0.087 mmol, 26% yield).