反应 #1256760

反应方程式

trifluoromethanesulphonic acid 4-(4-amino-phenyl)-3-cyano-6-cyclopropyl-pyridin-2-yl ester

1-fluoro-2-isocyanato-benzene

→

product

收率 66.0%

Trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester

收率 66.0%

反应条件

实验过程

In analogy to GP 4, reaction of 200 mg trifluoromethanesulphonic acid 4-(4-amino-phenyl)-3-cyano-6-cyclopropyl-pyridin-2-yl ester (0.522 mmol) and 71 μl 1-fluoro-2-isocyanato-benzene yielded 179 mg product (0.343 mmol, 66% yield).

来源