反应 #1256703

反应方程式

4-bromo-3,5-dimethyl-phenol

potassium carbonate

methyl iodide

→

title compound

收率 99.0%

2-bromo-5-methoxy-1,3-dimethyl-benzene

收率 99.0%

溶剂

acetone

反应条件

后处理

1. 1
   温度After cooling to room temperature
2. 2
   过滤the mixture was filtered
3. 3
   浓缩the filtrate was concentrated in vacuo
4. 4
   workup.DISTILLATIONThe resulting clear liquid was distilled under reduced pressure (70° C./0.1 Torr)

实验过程

To a mixture of 4-bromo-3,5-dimethyl-phenol (40.2 g, 0.200 mol) and potassium carbonate (55.2 g, 0.400 mol) in acetone (200 mL) was added methyl iodide ( 24.9 mL, 0.600 mol) at room temperature under N2. The reaction mixture was then refluxed at 65° C. for 8 h. After cooling to room temperature, the mixture was filtered, and the filtrate was concentrated in vacuo. The resulting clear liquid was distilled under reduced pressure (70° C./0.1 Torr) to give 42.4 g (99%) of title compound as a colorless liquid. 1H NMR (400 MHz, CDCl3): δ 6.663 (s, 2H), 3.778 (s, 3H), 2.402 (s, 6H); 13C NMR (100 MHz, CDCl3): δ 158.165, 139.203, 118.357, 113.953, 55.520, 24.319. MS (EI): m/z 214 [M+, 79Br 100], 216 [M+, 79Br, 96].

来源