反应 #1256

反应方程式

sodium borohydride

2-(4-acetylphenyl)-5-decyloxypyrimidine

ethanol

chloroform

→

2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine

收率 100.3%

溶剂

water

反应条件

后处理

1. 1
   其他equipped with a stirrer
2. 2
   其他The resulting reaction mixture
3. 3
   萃取followed by extraction and liquid separation
4. 4
   洗涤the obtained chloroform layer was washed with water
5. 5
   干燥dried over anhydrous magnesium sulfate
6. 6
   浓缩concentrated under reduced pressure

实验过程

35.5 g (0.1 mo1) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, 300 ml of ethanol and 300 ml of chloroform were supplied into a four-necked flask equipped with a stirrer and a thermometer. Then 2.8 g (0.075 mol) of sodium borohydride was added at 30°-40° C. and the mixture was stirred at the same temperature for 4 hours. The resulting reaction mixture was poured into 500 ml of water, followed by extraction and liquid separation, and the obtained chloroform layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 35.8 g of 2-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine (II-c-11) (yield: 100%).

来源