反应 #1253204

反应方程式

Phenylheptane

bromine

→

pure product

1-Bromo-4-heptylbenzene

溶剂

chloroform

反应条件

后处理

1. 1
   其他the reaction was quenched with 1N KOH
2. 2
   萃取After extraction
3. 3
   洗涤the organic phase was washed with water
4. 4
   干燥dried over MgSO4
5. 5
   其他was purified by column chromatography on silica gel

实验过程

Phenylheptane (100 g, 0.57 mol) was dissolved in 900 mL of chloroform, and ferric chloride (1.41 g, 9 mmol) was added. The mixture was cooled to 0° C. and bromine (32 mL, 0.62 mmol) was added dropwise through an additional funnel. The reaction was kept in dark to prevent the bromination of the aliphatic side chain. After stirring at room temperature overnight, the reaction was quenched with 1N KOH. After extraction, the organic phase was washed with water and dried over MgSO4. The crude product was a brown oil and was purified by column chromatography on silica gel using heptane as an eluent to give 60 g of pure product as light yellow oil at 42% yield. 1H NMR (CDCl3) δ (ppm): 0.88 (t, J=6.9 Hz, 3H), 1.26-1.31 (m, 8H), 1.54-1.59 (m, 2H), 2.54 (t, J=7.8 Hz, 2H), 7.04 (d, J=8.2 Hz, 2H), 7.38 (d, J=8.2 Hz, 2H). FD-MS: m/z 255 (M+).

来源