反应 #1253193

反应方程式

lauryl alcohol

triethyl amine

p-toluene sulphonyl chloride

→

lauryl tosylate

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   洗涤The reaction mixture was then washed with 20% sodium chloride solution (500 ml)
2. 2
   干燥The washed organic layer was dried over anhydrous sodium sulphate
3. 3
   其他Removal of solvent under vacuo
4. 4
   其他resulted in colorless oil that

实验过程

To a stirred and a cooled solution of lauryl alcohol (186.0 g, 1.0 mole) and triethyl amine (121.0 g, 1.2 mole) in dichloromethane (600 ml), p-toluene sulphonyl chloride (228.0 g, 1.2 mole) in dichloromethane (400 ml) was slowly added and the reaction was continued at room temperature for 10 hours. The reaction mixture was then washed with 20% sodium chloride solution (500 ml). The washed organic layer was dried over anhydrous sodium sulphate. Removal of solvent under vacuo resulted in colorless oil that solidified on keeping to yield lauryl tosylate. (309.0 g, 91%), m. p. 29° C. (literature m. p. 29° C.).

来源