反应 #1244307

反应方程式

Lithium borohydride

Methyl (2R)-3-(dibenzylamino)-2-fluoropropanoate

→

(2R)-3-(dibenzylamino)-2-fluoro-1-propanol

收率 93.0%

溶剂

THF

THF

反应条件

后处理

1. 1
   workup.ADDITIONadded dropwise to the mixture over 1 h
2. 2
   温度the internal temperature was maintained below −10° C. during the addition
3. 3
   workup.ADDITIONOn completion of addition
4. 4
   温度to warm to room temperature
5. 5
   workup.STIRRINGstirred at this temperature for 17 h
6. 6
   温度The reaction mixture was cooled to 0° C.
7. 7
   其他cautiously quenched with a saturated aqueous solution of ammonium chloride (300 mL)
8. 8
   萃取The reaction mixture was extracted with ethyl acetate (2×200 mL)
9. 9
   浓缩the organic phase was concentrated under reduced pressure
10. 10
    workup.DISSOLUTIONThe crude residue was dissolved in 2 N hydrochloric acid (200 mL, pH=2 approx.)
11. 11
    洗涤the aqueous phase was washed with ether (2×200 mL)
12. 12
    萃取extracted with ethyl acetate (3×200 mL)
13. 13
    干燥dried over anhydrous sodium sulfate (10 g)
14. 14
    过滤filtered
15. 15
    浓缩concentrated under reduced pressure

实验过程

Lithium borohydride (5.3 g, 0.24 mol) was suspended in THF (200 mL) under a nitrogen atmosphere and cooled to −15° C. with stirring. Methyl (2R)-3-(dibenzylamino)-2-fluoropropanoate (56.6 g, 0.19 mol) was suspended in THF (250 mL) and added dropwise to the mixture over 1 h; the internal temperature was maintained below −10° C. during the addition. On completion of addition, the reaction mixture was allowed to warm to room temperature and stirred at this temperature for 17 h. The reaction mixture was cooled to 0° C. and cautiously quenched with a saturated aqueous solution of ammonium chloride (300 mL). The reaction mixture was extracted with ethyl acetate (2×200 mL) and the organic phase was concentrated under reduced pressure. The crude residue was dissolved in 2 N hydrochloric acid (200 mL, pH=2 approx.) and the aqueous phase was washed with ether (2×200 mL). The aqueous phase was basified (pH=10 approx.) with 80% ammonium hydroxide in brine, extracted with ethyl acetate (3×200 mL), dried over anhydrous sodium sulfate (10 g), filtered and concentrated under reduced pressure to afford (2R)-3-(dibenzylamino)-2-fluoro-1-propanol (48 g, 93%) as a yellow oil.

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