反应 #1244284

反应方程式

sodium hydroxide

(S)-1,4-bis(methanesulfonyloxy)pentane

benzylamine

→

(R)-1-benzyl-2-methylpyrrolidine

收率 100.0%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   萃取an extraction
2. 2
   浓缩The organic layer was concentrated under a reduced pressure
3. 3
   其他to obtain a yellow oily substance
4. 4
   其他This product was purified by silica gel column chromatography

实验过程

First, 2.49 g (9.6 mmol) of (S)-1,4-bis(methanesulfonyloxy)pentane produced in Example 5 and 5.13 g (47.9 mmol) of benzylamine were stirred at 70° C. for three hours. Subsequently, 30 mL of ethyl acetate and 4.0 g of a 20 weight percent aqueous solution of sodium hydroxide were added to the mixture to perform an extraction. The organic layer was concentrated under a reduced pressure to obtain a yellow oily substance. This product was purified by silica gel column chromatography. Thus, (R)-1-benzyl-2-methylpyrrolidine was obtained as a light yellow oily substance (1.83 g, yield: 100%).

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