反应 #1244252

反应方程式

triethyl amine

Tetraethylene glycol

TBDMSCl

→

5c

收率 42.0%

2-(2-{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethanol

收率 42.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane)

实验过程

Tetraethylene glycol, 4c (1.12 g, 5.77 mmol) and TBDMSCl (0.87 g, 5.77 mmol) were dissolved in dichloromethane (25 ml) followed by triethyl amine (1.46 g, 14.4 mmol). The solution was stirred at room temperature for 2 hours. After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane) to afford 5c (744 mg, 42%): 1H NMR δ 3.66 (m, 16H), 2.51 (t, 1H, J=5.86 Hz), 0.89 (s, 9H), 0.07 (s, 6H).

来源