反应 #1227

反应方程式

water

sodium hydride

methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

iodomethane

→

methyl 2-methoxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

溶剂

DMF

DMF

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for two hours
2. 2
   萃取extracted with ethyl ether
3. 3
   其他the organic phase decanted
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他evaporated
6. 6
   其他1.6 g (96%) of the expected compound was recovered in the form of a colorless oil

实验过程

130 mg (4.2 mmol) of sodium hydride (80% in oil) and 20 ml of DMF were introduced into a three-necked flask, a solution of 1.6 g (4.2 mmol) of methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate in 50 ml of DMF was added dropwise and the mixture was stirred until gaseous emission ceased. 340 μl (5.5 mmol) of iodomethane were then added and the mixture was stirred at room temperature for two hours. The reaction medium was poured into water, extracted with ethyl ether, the organic phase decanted, dried over magnesium sulfate and evaporated. 1.6 g (96%) of the expected compound was recovered in the form of a colorless oil.

来源