反应 #1224

反应方程式

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

溶剂

water

ethyl ether

反应条件

后处理

1. 1
   其他the reaction medium evaporated to dryness
2. 2
   其他the residue obtained
3. 3
   其他The organic phase was decanted off
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他evaporated
6. 6
   其他The residue obtained
7. 7
   其他was triturated in heptane
8. 8
   过滤filtered
9. 9
   其他4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

实验过程

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

来源