反应 #1203

反应方程式

1-[N-Methyl-N-(2-hydroxyethyl)amino]-3-(12-hydroxyoctadecyl)-2-propanol

12-hydroxyoctadecyl glycidyl ether

N-methylethanolamine

N-(3-methoxy-2-hydroxy-propyl)-N-methyl-2-hydroxyethylamine

methyl bromide

→

title compound

收率 90.0%

N-(2-hydroxypropyl)-N,N-dimethyl-N-[3-(12-hydroxyoctadecyl)-2-hydroxypropyl]ammonium bromide

收率 90.0%

溶剂

diethyl ether

反应条件

后处理

1. 1
   浓缩The reaction mixture was then concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONthe resultant residue was dissolved in methanol
3. 3
   workup.ADDITIONDiethyl ether was added to the solution
4. 4
   其他to form crystals
5. 5
   过滤The crystals were collected by filtration

实验过程

1-[N-Methyl-N-(2-hydroxyethyl)amino]-3-(12-hydroxyoctadecyl)-2-propanol was first prepared from 12-hydroxyoctadecyl glycidyl ether and N-methylethanolamine in the same manner as in the preparation of N-(3-methoxy-2-hydroxy-propyl)-N-methyl-2-hydroxyethylamine in Preparation Example 24. A 200-ml autoclave was charged with 6.3 g (15 mmol) of the thus-prepared compound, 100 ml of diethyl ether and 14.2 g of methyl bromide, and the resultant mixture was stirred at 48° C. for 8 hours. The reaction mixture was then concentrated under reduced pressure, and the resultant residue was dissolved in methanol. Diethyl ether was added to the solution to form crystals. The crystals were collected by filtration, thereby obtaining 6.9 g (yield: 90%) of the title compound (IIb-4).

来源