反应 #11999
ord-c353e953aaf34bf5a0978f79193a0a6e
反应方程式
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1其他was obtained
- 2洗涤was washed with 1 N HCl (2×5 mL)
- 3干燥dried over MgSO4
- 4浓缩concentrated in vacuo
实验过程
Methyl trifluoroacetate (200 μL, 1.99 mmoles) and triethylamine (184 μL, 1.32 mmoles) were added to a suspension of 12-aminododecanoic acid (300 mg, 1.32 mmoles) in methanol (2 mL). After the mixture was stirred vigorously for 18 h, 1 N HCl was added dropwise until the a pH of 2 was obtained. The reaction was added to ethyl acetate (20 mL) was washed with 1 N HCl (2×5 mL), dried over MgSO4, and concentrated in vacuo to yield the amide as a white solid (398 mg, 1.28 mmoles, 97%). LRMS: not performed. 1H NMR: spectrum is consistent with the predicted structure.