反应 #1198

反应方程式

tetradecanol

NaH

methallyl chloride

m-chloroperbenzoic acid

→

1,2-epoxy-2-methyl-3-tetradecyloxypropane

收率 79.5%

溶剂

water

dimethylformamide

dichloromethane

反应条件

后处理

1. 1
   其他A 200-ml flask equipped with a stirrer
2. 2
   其他After completion of the reaction
3. 3
   萃取subjected to extraction with hexane
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
5. 5
   workup.ADDITIONThe resultant residue was charged into a 300-ml flask
6. 6
   其他equipped with a stirrer
7. 7
   其他Solids formed
8. 8
   其他were separated by filtration
9. 9
   浓缩the resultant solution was concentrated under reduced pressure
10. 10
    其他purified by column chromatography on silica gel

实验过程

A 200-ml flask equipped with a stirrer was charged with 10 g (46.6 mmol) of tetradecanol, 50 ml of dimethylformamide, 2.86 g (71.5 mmol) of 60% NaH and 5.96 g (65.8 mmol) of methallyl chloride. The contents were stirred at 60° C. for 15 hours. After completion of the reaction, the reaction mixture was added with water and subjected to extraction with hexane, and the solvent was distilled off under reduced pressure. The resultant residue was charged into a 300-ml flask equipped with a stirrer, and 12.24 g (70.9 mmol) of m-chloroperbenzoic acid and 200 ml of dichloromethane were added thereto. The resultant mixture was stirred at room temperature for 19 hours. Solids formed were separated by filtration, and the resultant solution was concentrated under reduced pressure and then purified by column chromatography on silica gel, thereby obtaining 10.54 g (yield: 79.4%) of 1,2-epoxy-2-methyl-3-tetradecyloxypropane as an intermediate.

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