反应 #11971

反应方程式

compound

(2S)-2-(4-(N-Boc-N-2-picolylamino)methylnaphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

hydrochloric acid dioxane

→

hydrochloride

title compound

(2S)-2-(4-(N-2-picolylaminomethyl)naphthalene-1-carbonyl)amino-5-((8S)-5,6,7,8-tetrahydroquinolin-8-yl)aminovaleric acid 1-naphthylmethylamide

溶剂

methanol

反应条件

后处理

1. 1
   其他After the reaction for 3.5 hours
2. 2
   浓缩the reaction solution was concentrated
3. 3
   其他The residue obtained
4. 4
   其他was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. 5
   workup.ADDITIONtreated with hydrochloric acid

实验过程

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

来源