反应 #1194

反应方程式

ethanolamine

10-(2-ethylhexyloxy)decyl glycidyl ether

→

title compound

收率 68.4%

1-(2-hydroxyethylamino)-3-[10-(2-ethylhexyloxy)decyloxy]-2-propanol

收率 68.4%

溶剂

ethanol

反应条件

后处理

1. 1
   其他A 200-ml two-necked flask equipped with a stirrer
2. 2
   温度reflux tube
3. 3
   温度While heating
4. 4
   workup.STIRRINGstirred further for 18 hours
5. 5
   浓缩it was concentrated under reduced pressure
6. 6
   其他the resultant residue was purified by column chromatography on silica gel

实验过程

A 200-ml two-necked flask equipped with a stirrer, reflux tube and dropping funnel was charged with 32.7 g (0.54 mol) of ethanolamine and 10.1 g of ethanol. While heating and stirring the mixture at 80° C., 1.76 g (5.14 mmol) of 10-(2-ethylhexyloxy)decyl glycidyl ether were added dropwise over 2 hours. After the resultant mixture was heated and stirred further for 18 hours, it was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 1.42 g (yield: 68%) of the title compound (Ia-14).

来源