反应 #1193

反应方程式

10-(2-ethylhexyloxy)decanol

epichlorohydrin

NaOH

→

10-(2-ethylhexyloxy)decyl glycidyl ether

收率 82.6%

溶剂

hexane

反应条件

后处理

1. 1
   其他A 200-ml flask equipped with a stirrer
2. 2
   温度reflux tube
3. 3
   其他After the resultant reaction mixture
4. 4
   洗涤was washed with water
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
6. 6
   其他the resultant residue was purified by column chromatography on silica gel

实验过程

A 200-ml flask equipped with a stirrer, reflux tube and dropping funnel was charged with 24.8 g (87 mmol) of 10-(2-ethylhexyloxy)decanol, 17.7 g (0.191 mol) of epichlorohydrin, 1.4 g (4.4 mmol) of tetrabutylammonium bromide and 25 ml of hexane. While stirring the mixture at 40° C., 29.2 g (0.35 mol) of a 48% aqueous solution of NaOH were added dropwise over 3 hours. After completion of the dropping, the stirring was continued further for 2 hours at 40° C. After the resultant reaction mixture was washed with water, and the solvent was distilled off under reduced pressure, the resultant residue was purified by column chromatography on silica gel, thereby obtaining 24.6 g (yield: 82.6%) of 10-(2-ethylhexyloxy)decyl glycidyl ether.

来源