反应 #1178481

反应方程式

p-toluenesulfonic acid monohydrate

→

title compound

1,4-Di-O-tosyl-D-threitol

溶剂

ethanol

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   温度the mixture was heated
3. 3
   温度to reflux for 4 days
4. 4
   温度The reaction liquor was cooled
5. 5
   浓缩the solvent was concentrated under reduced pressure
6. 6
   workup.ADDITIONA saturated aqueous solution of sodium hydrogen carbonate (50 mL) was added to the obtained residue
7. 7
   萃取the mixture was extracted with ethyl acetate
8. 8
   洗涤The extract was washed with saturated brine
9. 9
   干燥dried over anhydrous sodium sulfate
10. 10
    浓缩concentrated under reduced pressure

实验过程

To an ethanol (100 mL) suspension of 1,4 di-O-tosyl-2,3-O-isopropylidene-L-threitol (10.0 g, 21.25 mmol), p-toluenesulfonic acid monohydrate (0.40 g) was added, and the mixture was heated to reflux for 4 days with stirring. The reaction liquor was cooled, and then the solvent was concentrated under reduced pressure. A saturated aqueous solution of sodium hydrogen carbonate (50 mL) was added to the obtained residue, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to obtain the title compound as a solid. This compound was used in the subsequent reaction without performing further purification.

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