反应 #1178480

反应方程式

hydrochloric acid

Cis-4-(1-benzhydryl-3-azetidinyl)-2,6-dimethylmorpholine

→

title compound

收率 100.0%

Cis-4-(3-azetidinyl)-2,6-dimethylmorpholine hydrochloride

收率 100.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他The catalyst was removed by filtration
2. 2
   浓缩the solvent was concentrated under reduced pressure
3. 3
   workup.ADDITIONA 1N-hydrochloric acid (10 mL) was added to the obtained residue
4. 4
   洗涤the mixture was washed with diethylether
5. 5
   浓缩The aqueous layer was concentrated

实验过程

Cis-4-(1-benzhydryl-3-azetidinyl)-2,6-dimethylmorpholine (2.63 g, 7.82 mmol) was dissolved in methanol (40 mL), and 10% palladium hydroxide (wet) (500 mg) and a 1N-hydrochloric acid (5 mL) were added thereto. The mixture was stirred for 24 hours at room temperature under a hydrogen stream at normal pressure. The catalyst was removed by filtration, and the solvent was concentrated under reduced pressure. A 1N-hydrochloric acid (10 mL) was added to the obtained residue, and the mixture was washed with diethylether. The aqueous layer was concentrated to obtain the title compound (1.9 g, 100%) as an amorphous matter.

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