反应 #1178471

反应方程式

(1-Benzhydrylazetidin-3-yl)methanol

acetic acid

→

title compound

3-Azetidinemethanol acetate

溶剂

ethanol

反应条件

后处理

1. 1
   其他The catalyst was separated by filtration
2. 2
   浓缩the reaction liquor was concentrated under reduced pressure

实验过程

(1-Benzhydrylazetidin-3-yl)methanol (1.81 g, 7.16 mmol) was dissolved in ethanol (50 mL), and acetic acid (0.82 mL, 14.32 mmol) and 10% palladium hydroxide/carbon (1.2 g) were added at room temperature. The mixture was stirred for three days under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and the reaction liquor was concentrated under reduced pressure, to obtain the title compound as an oily matter. This compound was used in the subsequent reaction without being subjected to further purification.

来源