反应 #1178470

反应方程式

tetrahydrofuran

lithium aluminum hydride

tetrahydrofuran

1-benzhydrylazetidin-3-carboxylic acid methyl ester

sodium hydroxide

→

title compound

收率 108.6%

(1-Benzhydrylazetidin-3-yl)methanol

收率 108.6%

溶剂

water

water

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction mixture was stirred for 3.5 hours
2. 2
   workup.STIRRINGWhile the reaction mixture was stirred again under ice cooling
3. 3
   workup.STIRRINGthe mixture was stirred for 20 minutes
4. 4
   其他Precipitated insoluble matter was removed through separation by filtration
5. 5
   浓缩the obtained mother liquor was concentrated under reduced pressure

实验过程

To an anhydrous tetrahydrofuran solution (100 mL) of lithium aluminum hydride (1.14 g, 29.93 mmol), a tetrahydrofuran solution (50 mL) of 1-benzhydrylazetidin-3-carboxylic acid methyl ester (Oakwood Products, Inc.: Code No. W07L) (2.00 g, 7.16 mmol) was added dropwise over 10 minutes under ice cooling and stirring, and the reaction mixture was stirred for 3.5 hours. While the reaction mixture was stirred again under ice cooling, water (1.14 mL), a 4N-aqueous solution of sodium hydroxide (1.14 mL) and water (4.50 mL) were added to the reaction liquor, and the mixture was stirred for 20 minutes. Precipitated insoluble matter was removed through separation by filtration, and the obtained mother liquor was concentrated under reduced pressure to obtain the title compound (1.97 g, over yield) as an oily matter.

来源