反应 #1178464

反应方程式

thiourea

1,4-benzoquinone

→

2-amino-1,3-benzothiazol-6-ol

溶剂

ethanol

hydrochloric acid

ethanol

反应条件

后处理

1. 1
   浓缩concentrated to dryness
2. 2
   其他The residue was triturated with hot acetonitrile
3. 3
   过滤the resulting solid was filtered
4. 4
   其他dried

实验过程

The intermediate 2-amino-1,3-benzothiazol-6-ol was prepared according to a slightly modified literature procedure by Lau and Gompf: J. Org. Chem. 1970, 35, 4103-4108. To a stirred solution of thiourea (7.6 g, 0.10 mol) in a mixture of 200 mL ethanol and 9 mL concentrated hydrochloric acid was added a solution of 1,4-benzoquinone (21.6 g, 0.20 mol) in 400 mL of hot ethanol. The reaction was stirred for 24 hours at room temperature and then concentrated to dryness. The residue was triturated with hot acetonitrile and the resulting solid was filtered and dried.

来源