反应 #1178457

反应方程式

sodium hydride

1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

3-bromo-1-propene

→

1-tert-butyl 2-methyl (2R,4R)-4-allyloxypyrrolidine-1,2-dicarboxylate

收率 96.8%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   workup.STIRRINGto stir at room temperature for a further 12 hours
3. 3
   过滤The reaction mixture is then filtered
4. 4
   其他the filtrate is evaporated to dryness under reduced pressure
5. 5
   过滤After the precipitate has been filtered off
6. 6
   萃取the filtrate is extracted twice with 20 ml of ethyl acetate each time
7. 7
   干燥Drying of the combined organic phases over sodium sulfate and stripping-off of the solvent

实验过程

1.55 g (38.6 mmol) of sodium hydride are added in portions under nitrogen to the solution of 10.3 g (42 mmol) of 1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate and 36.34 ml (420 mmol) of 3-bromo-1-propene in 100 ml of dimethylformamide (DMF), and the mixture is subsequently stirred at room temperature for 15 minutes. 9.73 g (42 mmol) of silver oxide are then added in portions to the reaction mixture, and the reaction mixture is left to stir at room temperature for a further 12 hours: The reaction mixture is then filtered, the filtrate is evaporated to dryness under reduced pressure, and the residue is taken up in 20 ml of saturated citric acid solution. After the precipitate has been filtered off, the filtrate is extracted twice with 20 ml of ethyl acetate each time. Drying of the combined organic phases over sodium sulfate and stripping-off of the solvent gives 11.6 g of 1-tert-butyl 2-methyl (2R,4R)-4-allyloxypyrrolidine-1,2-dicarboxylate as a red-brown oil; ESI 286.

来源