反应 #1178456

反应方程式

ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

→

4-(3-oxomorpholin-4-yl)phenylacetic acid

溶剂

sodium hydroxide

ethanol

反应条件

后处理

1. 1
   其他The reaction mixture is evaporated
2. 2
   workup.DISSOLUTIONthe residue is dissolved in water
3. 3
   萃取The mixture is extracted with ethyl acetate
4. 4
   干燥the organic phase is dried over sodium sulfate
5. 5
   其他evaporated

实验过程

20.2 g (76.8 mmol) of ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate are dissolved in a solution of 3.37 g of sodium hydroxide in 40 ml of ethanol, and the reaction solution is stirred at room temperature for 18 hours. The reaction mixture is evaporated, and the residue is dissolved in water and acidified to a pH of 3 using 1N hydrochloric acid. The mixture is extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and evaporated, giving 4-(3-oxomorpholin-4-yl)phenylacetic acid as a yellowish solid; ESI 236.

来源