反应 #1178413

反应方程式

2,2-dimethoxypropane

p-toluenesulfonic acid monohydrate

→

(2,2-dimethyl-[1,3]dioxan-5-yl)-methanol

溶剂

DMF

反应条件

后处理

1. 1
   workup.ADDITIONwere added
2. 2
   其他As much solvent as possible was removed in vacuo
3. 3
   workup.DISTILLATIONthe remainder was purified by distillation under vacuum

实验过程

Triol 3-1 (1 eq.) was dissolved in DMF at a concentration of approximately 0.5 M and 2,2-dimethoxypropane (1.16 eq.) and p-toluenesulfonic acid monohydrate (0.03 eq.) were added. The solution was stirred for one or more days, and was quenched with TEA (0.5 eq.). As much solvent as possible was removed in vacuo and the remainder was purified by distillation under vacuum.

来源