反应 #1178392

反应方程式

hydrochloric acid

2-hydroxyindane

paraformaldehyde

calcium chloride

→

chloromethyl(2-indanyl)ether

收率 100.3%

溶剂

methylene chloride

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction mixture was agitated for 16 hours
2. 2
   其他After separated an organic layer from the mixture
3. 3
   其他the solvent was removed by distillation

实验过程

A mixture of 134 g of 2-hydroxyindane, 36.1 g of paraformaldehyde, 200 g of calcium chloride, and 1200 g of methylene chloride was agitated. Into the mixture was dropped 239 g of a concentrated hydrochloric acid at room temperature for 3 hours, and then the reaction mixture was agitated for 16 hours. After separated an organic layer from the mixture, the solvent was removed by distillation to obtain 183 g of chloromethyl(2-indanyl)ether as an oily matter.

来源