反应 #1174

反应方程式

K2CO3

1-Benzyloxycarbonyl-4-phthalimidylpiperidine

hydrazine monohydrate

→

4-amino-1-benzyloxycarbonylpiperidine

收率 85.0%

溶剂

ethanol

Brine

反应条件

后处理

1. 1
   萃取the mixture was extracted with 5% MeOH/CHCl3 (3×)
2. 2
   洗涤The combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution
3. 3
   干燥dried over Na2SO4
4. 4
   浓缩concentrated

实验过程

1-Benzyloxycarbonyl-4-phthalimidylpiperidine (1.50 g, 4.27 mmol), prepared in Example 16B, was taken up in 20 mL of ethanol. To this solution was added hydrazine monohydrate (35 mL, 700 mmol) and this mixture was heated at 100° C. for 3 h. Brine solution (40 mL) and 10% aq. K2CO3 (60 mL) were added and the mixture was extracted with 5% MeOH/CHCl3 (3×). The combined extracts were washed with 2N aq. HCl, 2N aq. NaOH, brine solution, dried over Na2SO4 and concentrated to give 0.847 g, (85%) of 4-amino-1-benzyloxycarbonylpiperidine. [1H]-NMR(CDCl3) consistent with structure.

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