反应 #1171

反应方程式

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

收率 35.0%

溶剂

EtOAc

DMSO

反应条件

后处理

1. 1
   洗涤washed with 1N aq. HCl, 5N aq. NaOH
2. 2
   干燥dried over MgSO4
3. 3
   浓缩concentrated

实验过程

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

来源