反应 #1166460

反应方程式

hydrochloric acid

triethylamine

trans-4-n-propylcyclohexanecarbonyl chloride

water

→

ethyl trans-4-n-propylcyclohexylcarboxylate

溶剂

ethanol

反应条件

后处理

1. 1
   萃取extracted with isopropyl ether
2. 2
   洗涤The organic layer was repeatedly washed with water until the aqueous layer
3. 3
   干燥by drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography

实验过程

A small amount of triethylamine was added to 10 g (53.6 mmol) of trans-4-n-propylcyclohexanecarbonyl chloride dissolved in 30 ml of ethanol, followed by 10 hours of stirring at room temperature. The reaction mixture was poured into 100 ml of iced water, acidified with 6N-hydrochloric acid and extracted with isopropyl ether. The organic layer was repeatedly washed with water until the aqueous layer became neutral, followed by drying with magnesium sulfate, distilling-off of the solvent and purification by silica gel column chromatography to obtain 9.9 g of ethyl trans-4-n-propylcyclohexylcarboxylate.

来源