反应 #1161

反应方程式

acetic acid

KMnO4

4-(methylthio)acetophenone

sodium sulfite

→

4-(methylsulfonyl)acetophenone

溶剂

water

water

反应条件

后处理

1. 1
   其他to return to room temperature
2. 2
   workup.WAITThis is left
3. 3
   其他The solid obtained
4. 4
   过滤is filtered off
5. 5
   洗涤washed copiously with water
6. 6
   其他recrystallized from 95% ethanol

实验过程

A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.

来源