反应 #11523

反应方程式

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

反应条件

后处理

1. 1
   温度After cooling
2. 2
   萃取extracted twice with ethyl acetate
3. 3
   洗涤The combined solvent phase was washed twice with brine
4. 4
   干燥dried (magnesium sulphate)
5. 5
   其他evaporated

实验过程

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

来源