反应 #1139411

反应方程式

methyl 2-[(tert-butoxycarbonyl)(prop-2-en-1-yl)amino]pent-4-enoate

tetrahydrofuran

diisobutylaluminum hydride toluene

→

title compound

收率 83.9%

tert-butyl [1-(hydroxymethyl)but-3-en-1-yl]prop-2-en-1-ylcarbamate

收率 83.9%

溶剂

potassium sodium tartrate

反应条件

后处理

1. 1
   萃取the mixture was extracted with ethyl acetate
2. 2
   干燥The extract was dried over anhydrous sodium sulfate
3. 3
   过滤Insoluble material was filtered off
4. 4
   浓缩the filtrate was concentrated under reduced pressure

实验过程

To a mixture of methyl 2-[(tert-butoxycarbonyl)(prop-2-en-1-yl)amino]pent-4-enoate (5.0 g) produced above and tetrahydrofuran (100 mL) was added 1M diisobutylaluminum hydride/toluene solution (60 mL) at 0° C., and the mixture was stirred at the same temperature for 15 min. The reaction mixture was diluted with aqueous potassium sodium tartrate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (3.76 g).

来源