反应 #1138870

反应方程式

Sodium borohydride

3-(benzyloxy)cyclobutanone

tetrahydrofuran

methanol

→

3-(benzyloxy)cyclobutanol

收率 90.1%

溶剂

water

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate (2×30 mL)
2. 2
   干燥The combined organic layers were dried over anhydrous sodium sulfate
3. 3
   过滤filtered
4. 4
   浓缩concentrated

实验过程

A 100-mL round-bottom flask was charged with 3-(benzyloxy)cyclobutanone (2.00 g, 11.4 mmol), tetrahydrofuran (20 mL), and methanol (1 mL), and the solution was cooled to 0° C. Sodium borohydride (0.475 g, 12.5 mmol) was added portionwise, and the resulting mixture stirred for 30 min at room temperature. The reaction mixture was poured into water (30 mL), and extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated to afford 3-(benzyloxy)cyclobutanol (1.83 g, 90%) as yellow oil. MS (ESI, pos. ion) m/z 179 [M+H]+.

来源