反应 #1138624

反应方程式

4-((5-bromo-1H-pyrazol-1-yl)methyl)benzoic acid

pyrrolidine

EDC HOBt

→

product

收率 99.0%

(4-((5-bromo-1H-pyrazol-1-yl)methyl)phenyl)(pyrrolidin-1-yl)methanone

收率 99.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他The mixture was evaporated in vacuuo
2. 2
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
3. 3
   洗涤washed with water
4. 4
   其他The separated organic layer was dried
5. 5
   浓缩concentrated

实验过程

4-((5-bromo-1H-pyrazol-1-yl)methyl)benzoic acid (200 mg, 0.71 mmol), pyrrolidine (61 mg, 0.85 mmol) and EDC-HOBt (452 mg, 2 mmol) were combined in CH2Cl2 and stirred for 4 h at room temperature. The mixture was evaporated in vacuuo and the residue dissolved in ethyl acetate and washed with water. The separated organic layer was dried and concentrated affording the product as an oil (231 mg, yield 99%), which was used in next step without further purification. LCMS (m/z): 334.2 [M+H]+

来源